Welcome to the Cellular Mechanobiology Lab
Our laboratory seeks to understand how cells respond to biomechanical cues present in the extracellular matrix (ECM).
The ability of living cells to sense and respond to complex tissue environments fundamentally regulates key physiological and pathological processes, including embryogenesis, regeneration, and tumor invasion. To better understand cell-matrix interactions in heterogeneous micro-environments, we adopt a multidisciplinary approach combining methods and concepts from biomaterials, microfluidics, molecular and cell biology, microscopy, applied mechanics, and computational modeling.
- May 2018: Publication in ACS Biomaterials Science & Engineering on a new micropatterning technique and weakening of junctions in cell pairs.
- May 2018: Publication in Integrative Biology on cell response to basement membrane defects (WashU story).
- Jan 2018: NIH/NIBIB Trailblazer Award, in collaboration with Dr. Klechevsky.
- Jan 2018: Two-year pilot grant for immuno-mechanobiology research.
- Sep 2017: Publication in Biomaterials on mechanical memory in cell migration (WashU story).
- Sep 2017: Samila submits doctoral thesis. Congrats, Dr. Nasrollahi!
- Jul 2017: Siteman Investment Program grant.
- Apr 2017: Publication in Biophysical Journal on increased stiffness of optic nerve glioma.
- Jan 2015: NSF CAREER Award to Amit.
- Oct 2014: Mallinckrodt Foundation New Investigator Award.