Welcome to the Cellular Mechanobiology Lab
Our laboratory seeks to understand how cells respond to biomechanical cues present in the extracellular matrix (ECM).
The ability of living cells to sense and respond to complex tissue environments fundamentally regulates key physiological and pathological processes, including embryogenesis, regeneration, and tumor invasion. To better understand cell-matrix interactions in heterogeneous micro-environments, we adopt a multidisciplinary approach combining methods and concepts from biomaterials, microfabrication, molecular and cell biology, microscopy, applied mechanics, and computational modeling.
- Sep 2019: Publication in the Journal of Cell Science on collective cell streaming due to varying collagen fiber length and matrix stiffness.
- Nov 2018: Publication in Biophysical Journal on cell re-polarization in collective cell migration. (WashU story)
- Jul 2018: We have received a 5-year NIH/NIGMS R35 MIRA grant for research in epithelial cell mechanobiology. We have doctoral and postdoctoral positions open.
- May 2018: Publication in ACS Biomaterials Science & Engineering on a new micropatterning technique and weakening of junctions in cell pairs.
- May 2018: Publication in Integrative Biology on cell response to basement membrane defects (WashU story).
- Jan 2018: NIH/NIBIB Trailblazer grant, in collaboration with Dr. Klechevsky.
- Jan 2018: Two-year pilot grant for mechanobiology of immune cells.
- Sep 2017: Publication in Biomaterials on mechanical memory in cell migration (WashU story).