WJ Lin and A Pathak* (2023) Transitions in density, pressure, and effective temperature drive collective cell migration into confining environments. bioRxiv.
A Bagchi, B Sarker, J Zhang, M Foston, A Pathak* (2022) A fast yet force-effective mode of collective cell migration on aligned fibers due to rapid stabilization of contractile forces. bioRxiv.
J Mathur, VB Shenoy, A Pathak* (2020) Mechanical memory in cells emerges from mechanotransduction with transcriptional feedback and epigenetic plasticity. bioRxiv.
YL Lee, J Mathur, C Walter, H Zmuda, and A Pathak* (2023) Matrix obstructions cause multiscale disruption in collective epithelial migration by suppressing leader cell function. MBoC. [Link].
H Zmuda and A Pathak* (2023) Epithelial multicellular clustering enabled by polarized macrophages on soft matrices. The FASEB Journal. [Link].
C Walter, J Mathur, and A Pathak* (2023) Reciprocal Intra- and Extra-Cellular Polarity Enables Deep Mechanosensing Through Layered Matrices. Cell Reports. [Link].
CM Krull, H Li, A Pathak* (2023) Nuclear export inhibition jumbles epithelial-mesenchymal states and gives rise to migratory disorder in healthy epithelia. eLife. [Link]
JA Almeida, J Mathur, YL Lee, B Sarker, and A Pathak* (2023) Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality. Molecular Biology of the Cell. [Link]
PY Hwang, J Mathur, Y Cao, J Almeida, J Ye, V Morikis, D Cornish, M Clarke, SA Stewart, A Pathak, and GD Longmore* (2023) A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration. Developmental Cell, 58(1), 34-50.e9. [Link]
FF Jaecker, JA Almeida, CM Krull, A Pathak* (2022) Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues. Molecular Biology of the Cell. [Link]
CC Price§, J Mathur§, JD Boerckel, A Pathak*, VB Shenoy* (2021) Dynamic Self-Reinforcement of Gene Expression Determines Acquisition and Retention of Cellular Mechanical Memory. Biophysical Journal. [Link] (preprint)
MN Barcellona, JE Speer, BV Fearing, L Jing, A Pathak, MC Gupta, JM Buchowski, M Kelly, and LA Setton* (2020) Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype. Biomaterials, 250, 120057. [Link]
B Sarker§, A Bagchi§, C Walter, J Almeida, A Pathak* (2019) Longer collagen fibers trigger multicellular streaming on soft substrates via enhanced forces and cell-cell cooperation. Journal of Cell Science. [Link]
BV Fearing, L Jing, MN Barcellona, SE Witte,JM Buchowski, LP Zebala, MP Kelly, S Luhmann, MC Gupta, A Pathak, and LA Setton* (2019) Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape. The FASEB Journal. [Link]
SVH Bayer, WR Grither, A Brenot, PY Hwang, CE Barcus, M Ernst, P Pence, C Walter, A Pathak, & GD Longmore* (2019) DDR2 controls breast tumor stiffness and metastasis by regulating Integrin mediated mechanotransduction in CAFs. eLife. [Link]
J Mathur, B Sarker, and A Pathak* (2018). Predicting collective migration of cell populations defined by varying re-polarization dynamics. Biophysical Journal. [Link]
B Sarker, C Walter, and A Pathak* (2018). Direct micropatterning of ECM proteins on functionalized polyacrylamide hydrogels shows geometric regulation of cell-cell junctions. ACS Biomaterials Science & Engineering. [Link]
C Walter§, J Davis§, J Mathur and A Pathak* (2018). Physical defects in basement membrane-like collagen-IV matrices trigger mesenchymal transition in normal epithelial cells. Integrative Biology. (§equal contribution) [Link] (WashU News story) (Journal cover)
A Pathak* (2018). Modeling and predictions of biphasic mechanosensitive cell migration altered by cell-intrinsic properties and matrix confinement. Physical Biology. [Link]
S Nasrollahi, C Walter, AJ Loza, GV Schimizzi, GD Longmore, and A Pathak* (2017). Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory. Biomaterials. [Link] (WashU News story; EurekAlert, F1000 Recommended)
S Nasrollahi and A Pathak* (2017). Hydrogel-based microchannels to measure confinement- and stiffness-sensitive YAP activity in epithelial clusters. MRS Communications. [Link]
C Walter§, L Crawford§, M Lai, JA Toonen, Y Yuan, S Sakiyama-Elbert, DH Gutmann, A Pathak* (2017), Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma. Biophysical Journal, V. 112, 1535-1538. (§ equal contribution) [Link]
S Nasrollahi, S Banerjee, B Qayum, P Banerjee, A Pathak* (2016). Nano-scale matrix topography influences micro-scale cell motility through adhesions, actin organization, and cell shape. ACS Biomaterials Science & Engineering. [Link]
S Nasrollahi and A Pathak* (2016). Topographic confinement of epithelial clusters induces epithelial-to-mesenchymal transition in compliant matrices. Scientific Reports. [Link]
A Pathak and S Kumar (2013). Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration. Integrative Biology, Vol. 5(8), 1067-75. [Link]
A Pathak and S Kumar (2012). Independent regulation of tumor cell migration by matrix stiffness and confinement. Proceedings of the National Academy of Sciences USA, Vol. 109(26), 10334-10339. [Link]
A Pathak and S Kumar (2011). From molecular signal activation to locomotion: An integrated, multiscale analysis of cell motility on defined matrices. PLoS ONE, 6(3): e18423. [Link]
W Ronan, A Pathak, VS Deshpande, RM McMeeking and JP McGarry (2013). Simulation of the Mechanical Response of Cells on Micro-post Substrates. Journal of Biomechanical Engineering, 135(10), 101012. [Link]
A Pathak, CS Chen, AG Evans and RM McMeeking (2012). Structural mechanics based model for the force-bearing elements within the cytoskeleton of a cell adhered on a bed of posts. Journal of Applied Mechanics, Vol. 79(6), 061020-27. [Link]
A Pathak, RM McMeeking, AG Evans and VS Deshpande (2011). An analysis of the co-operative mechano-sensitive feedback between intracellular signaling, focal adhesion development and stress fiber contractility. Journal of Applied Mechanics, Vol. 78(4), 041001-11. [Link]
WR Legant, A Pathak, MT Yang, VS Deshpande, RM McMeeking and CS Chen (2009). Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues. Proceedings of the National Academy of Sciences USA, Vol. 106(25), 10097-10102. [Link]
A Pathak, VS Deshpande, RM McMeeking and AG Evans (2008). The simulation of stress fibre and focal adhesion development in cells on patterned substrates. Journal of the Royal Society Interface, Vol. 5, 507-524. [Link]
A Pathak and RM McMeeking (2008). Three-dimensional finite element simulations of ferroelectric polycrystals under electrical and mechanical loading. Journal of the Mechanics and Physics of Solids, Vol. 56, 663-683. [Link]
Reviews and Book Chapters
C Walter, H Zmuda, JA Almeida, A Pathak*, Cell-matrix interactions, force transmission, and mechano-sensation, Cell Movement in Health and Disease. [Link]
A Pathak and S Kumar (2011). Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness. Integrative Biology, Vol. 3(4): 267-278. [Link]
A Pathak, VS Deshpande, AG Evans and RM McMeeking (2013). Simulations of cell behavior on substrates of variegated stiffness and architecture. Computer Models in Biomechanics, pp 25-41. Dordrecht: Springer Netherlands. [Link]